International Review of Ophthalmology ›› 2023, Vol. 47 ›› Issue (3): 276-282.doi: 10.3760/ cma.j.issn.1673-5803.2023.03.014

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Relationship between reticular macular disease and systemic microvascular dysfunction

Chu Zhe1, Ren Qi1, Cheng Lu2, Cheng Hao3   

  1. 1Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, School of Ophthalmology, Shandong First Medical University, Qingdao 266071, China; 2Zhongshan Ophthalmic Centre, Sun Yat-sen University, State Key Laboratory of Ophthalmology, Guangzhou 510060, China; 3Department of Ophthalmology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China
  • Received:2022-10-08 Online:2023-06-22 Published:2023-06-29
  • Contact: Cheng Hao, Email: chrischenghao@gzhmu.edu.cn
  • Supported by:
    Science and Technology Program of Guangzhou(202201020458)

Abstract: Reticular macular disease (RMD) is an important phenotype of early and intermediate-stage age-related macular degeneration, which is closely related to choroidal capillary layer perfusion disorders, i.e., microcirculation disorders. Microcirculation dysfunction can lead to tissue dysfunction, especially for the eyes, kidney, heart and other hypermetabolic organs. Several studies indicate RMD may be part of a multisystem disorder affecting other vascular beds such as the kidney and heart. Microcirculatory disorders in kidney, heart and other organs are related to the occurrence of RMD, and they are intrinsically related in their pathogenesis. RMD may be used as a predictor of chronic kidney disease, coronary artery disease or coronary artery microcirculation disorders. (Int Rev Ophthalmol, 2023, 47: 276-282)

Key words: reticular macular disease, age-related macular degeneration, microcirculation disorders, chronic kidney disease, coronary artery disease